How long should antibiotic therapy be given in COPD exacerbations?

In the management of COPD exacerbations, the recommended duration for antibiotic therapy is generally 5-7 days. This duration is supported by clinical guidelines focused on ensuring efficacy while minimizing the risks associated with prolonged antibiotic use, such as antibiotic resistance and potential side effects.

Short courses of antibiotics, particularly in the context of exacerbations that are characterized by increased purulent sputum and other specific symptoms, have been shown to be effective in hastening recovery and improving lung function. Studies have indicated that extending antibiotic therapy beyond this range does not significantly enhance outcomes but increases the potential for adverse effects.

Therefore, the answer aligns with clinical practice that balances treatment effectiveness with safety considerations for the patient.