What contraindication is associated with expectorants?

The association of contraindication with expectorants in patients with phenylketonuria is due to the presence of artificial sweeteners, particularly aspartame, which is often found in liquid formulations of expectorants. Aspartame is a source of phenylalanine, an amino acid that individuals with phenylketonuria cannot metabolize effectively. This can lead to elevated levels of phenylalanine in the blood, potentially causing serious neurological issues.

In contrast, while expectorants can be used with caution in patients with asthma, COPD, or severe headaches, the specific concern for phenylketonuria is significant due to the metabolic limitations that these patients face. Therefore, the contraindication linked to expectorants primarily applies to this condition.