What should be monitored when administering Zileuton?

Zileuton is a leukotriene synthesis inhibitor used primarily in the management of asthma, particularly in patients who require additional control beyond inhaled corticosteroids. When administering Zileuton, it is essential to monitor liver function tests due to the potential risk of hepatotoxicity. The drug can cause an elevation in liver enzymes, which indicates liver injury or dysfunction. Regular monitoring helps to ensure that any liver-related side effects are detected early, allowing for timely intervention if necessary.

This vigilance is particularly important when starting therapy or adjusting dosages, as the likelihood of liver enzyme elevations can increase. Monitoring liver function tests, often including alanine aminotransferase (ALT) and aspartate aminotransferase (AST), enables healthcare providers to manage the patient's safety effectively while optimizing asthma control.

Other parameters, such as blood pressure, renal function, and blood glucose levels, are not routinely associated with Zileuton administration and do not require the same level of careful monitoring in the context of this medication.