Which of the following is a common counseling point for second generation antihistamines?

Second-generation antihistamines are typically chosen for their specific pharmacological properties, which include fewer sedative effects compared to first-generation antihistamines. However, fexofenadine, in particular, has a unique absorption profile that requires it to be taken with water for optimal efficacy. This is due to the fact that fexofenadine's absorption can be impaired by certain foods, especially those high in fat, and thus taking it with water ensures that it is effectively absorbed into the bloodstream.

The other common counseling points for second-generation antihistamines include that they are generally non-sedating or have minimal sedation, making them suitable for daytime use. This is a key reason why they are preferred for patients who need to avoid drowsiness while managing allergic symptoms. Additionally, these medications can indeed be used on an as-needed basis, as they provide symptom relief without the sedative burden of older agents.