Which of the following is a common adverse effect of intranasal antihistamines?

Nasal irritation is a common adverse effect associated with intranasal antihistamines. These medications are designed to be delivered directly into the nasal passages to provide localized relief from allergy symptoms. The nature of their application can lead to irritation of the nasal mucosa, resulting in symptoms such as burning, stinging, or even increased nasal discharge. This localized reaction is not uncommon and is often noted by patients upon initiation of therapy.

Understanding the mechanism of action of intranasal antihistamines helps contextualize this side effect; as they block the effects of histamine in the nasal cavity, the active ingredients can sometimes cause irritation, particularly in sensitive individuals or with prolonged use. Recognizing this effect allows healthcare providers to offer management strategies to mitigate discomfort while continuing to provide effective treatment for allergic rhinitis symptoms.